If you were born a physical male you are a man all your life. If you deem yourself transexual, you are merely short of testosterone, and need treating with it.
If you were born a physical female, you are a woman all your life. If you are using the surname on your birth certificate, your title is Miss. If you have changed your surname, your title is Mrs. For example, the well-known lawyer is known as either Mrs Cherie Blair or Miss Cherie Booth. If you combine both surnames, usually hyphenated, your correct title is Mrs.
No arguments, please, since I would refuse to listen.